Abnormalities of Dopamine D3 Receptor Signaling in the Diseased Brain
نویسندگان
چکیده
منابع مشابه
Abnormalities of Dopamine D3 Receptor Signaling in the Diseased Brain
Dopamine D3 receptors (D3R) modulate neuronal activity in several brain regions including cortex, striatum, cerebellum, and hippocampus. A growing body of evidence suggests that aberrant D3R signaling contributes to multiple brain diseases, such as Parkinson's disease, essential tremor, schizophrenia, and addiction. In line with these findings, D3R has emerged as a potential target in the treat...
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Dopamine (DA) is one of the main catecholamines in the brain and is crucial for movement coordination, endocrine function, reward, mood, memory and emotions. The dopaminergic system is the primary therapeutic target in the treatment of Parkinson’s disease (PD), drug addiction and schizophrenia. Notwithstanding, dysfunction of central dopaminergic neurotransmission has also been associated to de...
متن کاملp139: role of dopamine receptor d3 in depression and anxiety
dopamine (da) is one of the main catecholamines in the brain and is crucial for movement coordination, endocrine function, reward, mood, memory and emotions. the dopaminergic system is the primary therapeutic target in the treatment of parkinson’s disease (pd), drug addiction and schizophrenia. notwithstanding, dysfunction of central dopaminergic neurotransmission has also been associated to de...
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During last 15 years dopamine has emerged as a major regulator of inflammation. All five dopamine receptors (DRs, DRD1-DRD5) have been found to be expressed in immune cells where they exert a complex regulation of immunity [1]. Of note, DRs have been found not only in cells of the adaptive immune system, but also in cells belonging to the innate immunity, even including glial cells. The outcome...
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ژورنال
عنوان ژورنال: Journal of Central Nervous System Disease
سال: 2017
ISSN: 1179-5735,1179-5735
DOI: 10.1177/1179573517726335